Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.
Identifieur interne : 000560 ( Main/Exploration ); précédent : 000559; suivant : 000561Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.
Auteurs : Devon M. Headen [États-Unis] ; Kyle B. Woodward [États-Unis] ; María M. Coronel [États-Unis] ; Pradeep Shrestha [États-Unis] ; Jessica D. Weaver [États-Unis] ; Hong Zhao [États-Unis] ; Min Tan [États-Unis] ; Michael D. Hunckler [États-Unis] ; William S. Bowen [États-Unis] ; Christopher T. Johnson [États-Unis] ; Lonnie Shea [États-Unis] ; Esma S. Yolcu [États-Unis] ; Andrés J. García [États-Unis] ; Haval Shirwan [États-Unis]Source :
- Nature materials [ 1476-1122 ] ; 2018.
Descripteurs français
- KwdFr :
- Animaux (MeSH), Immunomodulation (effets des médicaments et des substances chimiques), Ligand de Fas (métabolisme), Ligand de Fas (pharmacologie), Matériaux biocompatibles (métabolisme), Matériaux biocompatibles (pharmacologie), Souris (MeSH), Streptavidine (métabolisme), Transplantation d'ilots de Langerhans (immunologie), Transplantation homologue (MeSH).
- MESH :
- effets des médicaments et des substances chimiques : Immunomodulation.
- immunologie : Transplantation d'ilots de Langerhans.
- métabolisme : Ligand de Fas, Matériaux biocompatibles, Streptavidine.
- pharmacologie : Ligand de Fas, Matériaux biocompatibles.
- Animaux, Souris, Transplantation homologue.
English descriptors
- KwdEn :
- Animals (MeSH), Biocompatible Materials (metabolism), Biocompatible Materials (pharmacology), Fas Ligand Protein (metabolism), Fas Ligand Protein (pharmacology), Immunomodulation (drug effects), Islets of Langerhans Transplantation (immunology), Mice (MeSH), Streptavidin (metabolism), Transplantation, Homologous (MeSH).
- MESH :
- chemical , metabolism : Biocompatible Materials, Fas Ligand Protein, Streptavidin.
- chemical , pharmacology : Biocompatible Materials, Fas Ligand Protein.
- drug effects : Immunomodulation.
- immunology : Islets of Langerhans Transplantation.
- Animals, Mice, Transplantation, Homologous.
Abstract
Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. A short course of rapamycin treatment boosted the immunomodulatory efficacy of SA-FasL microgels, resulting in acceptance and function of allografts over 200 days. Survivors generated normal systemic responses to donor antigens, implying immune privilege of the graft, and had increased CD4+CD25+FoxP3+ T regulatory cells in the graft and draining lymph nodes. Deletion of T regulatory cells resulted in acute rejection of established islet allografts. This localized immunomodulatory biomaterial-enabled approach may provide an alternative to chronic immunosuppression for clinical islet transplantation.
DOI: 10.1038/s41563-018-0099-0
PubMed: 29867165
PubMed Central: PMC6060019
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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García</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Shirwan, Haval" sort="Shirwan, Haval" uniqKey="Shirwan H" first="Haval" last="Shirwan">Haval Shirwan</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:29867165</idno><idno type="pmid">29867165</idno><idno type="doi">10.1038/s41563-018-0099-0</idno><idno type="pmc">PMC6060019</idno><idno type="wicri:Area/Main/Corpus">000537</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000537</idno><idno type="wicri:Area/Main/Curation">000537</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000537</idno><idno type="wicri:Area/Main/Exploration">000537</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.</title><author><name sortKey="Headen, Devon M" sort="Headen, Devon M" uniqKey="Headen D" first="Devon M" last="Headen">Devon M. Headen</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Woodward, Kyle B" sort="Woodward, Kyle B" uniqKey="Woodward K" first="Kyle B" last="Woodward">Kyle B. Woodward</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Coronel, Maria M" sort="Coronel, Maria M" uniqKey="Coronel M" first="María M" last="Coronel">María M. Coronel</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Shrestha, Pradeep" sort="Shrestha, Pradeep" uniqKey="Shrestha P" first="Pradeep" last="Shrestha">Pradeep Shrestha</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Weaver, Jessica D" sort="Weaver, Jessica D" uniqKey="Weaver J" first="Jessica D" last="Weaver">Jessica D. Weaver</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Zhao, Hong" sort="Zhao, Hong" uniqKey="Zhao H" first="Hong" last="Zhao">Hong Zhao</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Tan, Min" sort="Tan, Min" uniqKey="Tan M" first="Min" last="Tan">Min Tan</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Hunckler, Michael D" sort="Hunckler, Michael D" uniqKey="Hunckler M" first="Michael D" last="Hunckler">Michael D. Hunckler</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Bowen, William S" sort="Bowen, William S" uniqKey="Bowen W" first="William S" last="Bowen">William S. Bowen</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Johnson, Christopher T" sort="Johnson, Christopher T" uniqKey="Johnson C" first="Christopher T" last="Johnson">Christopher T. Johnson</name><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Shea, Lonnie" sort="Shea, Lonnie" uniqKey="Shea L" first="Lonnie" last="Shea">Lonnie Shea</name><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Yolcu, Esma S" sort="Yolcu, Esma S" uniqKey="Yolcu E" first="Esma S" last="Yolcu">Esma S. Yolcu</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Garcia, Andres J" sort="Garcia, Andres J" uniqKey="Garcia A" first="Andrés J" last="García">Andrés J. García</name><affiliation wicri:level="2"><nlm:affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Shirwan, Haval" sort="Shirwan, Haval" uniqKey="Shirwan H" first="Haval" last="Shirwan">Haval Shirwan</name><affiliation wicri:level="2"><nlm:affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Microbiology and Immunology, University of Louisville, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author></analytic><series><title level="j">Nature materials</title><idno type="ISSN">1476-1122</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Biocompatible Materials (metabolism)</term><term>Biocompatible Materials (pharmacology)</term><term>Fas Ligand Protein (metabolism)</term><term>Fas Ligand Protein (pharmacology)</term><term>Immunomodulation (drug effects)</term><term>Islets of Langerhans Transplantation (immunology)</term><term>Mice (MeSH)</term><term>Streptavidin (metabolism)</term><term>Transplantation, Homologous (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Immunomodulation (effets des médicaments et des substances chimiques)</term><term>Ligand de Fas (métabolisme)</term><term>Ligand de Fas (pharmacologie)</term><term>Matériaux biocompatibles (métabolisme)</term><term>Matériaux biocompatibles (pharmacologie)</term><term>Souris (MeSH)</term><term>Streptavidine (métabolisme)</term><term>Transplantation d'ilots de Langerhans (immunologie)</term><term>Transplantation homologue (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Biocompatible Materials</term><term>Fas Ligand Protein</term><term>Streptavidin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Biocompatible Materials</term><term>Fas Ligand Protein</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Immunomodulation</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Immunomodulation</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Transplantation d'ilots de Langerhans</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Islets of Langerhans Transplantation</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Ligand de Fas</term><term>Matériaux biocompatibles</term><term>Streptavidine</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Ligand de Fas</term><term>Matériaux biocompatibles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Mice</term><term>Transplantation, Homologous</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Souris</term><term>Transplantation homologue</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. A short course of rapamycin treatment boosted the immunomodulatory efficacy of SA-FasL microgels, resulting in acceptance and function of allografts over 200 days. Survivors generated normal systemic responses to donor antigens, implying immune privilege of the graft, and had increased CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> T regulatory cells in the graft and draining lymph nodes. Deletion of T regulatory cells resulted in acute rejection of established islet allografts. This localized immunomodulatory biomaterial-enabled approach may provide an alternative to chronic immunosuppression for clinical islet transplantation.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29867165</PMID><DateCompleted><Year>2019</Year><Month>05</Month><Day>10</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>23</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">1476-1122</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>8</Issue><PubDate><Year>2018</Year><Month>08</Month></PubDate></JournalIssue><Title>Nature materials</Title><ISOAbbreviation>Nat Mater</ISOAbbreviation></Journal><ArticleTitle>Local immunomodulation Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance.</ArticleTitle><Pagination><MedlinePgn>732-739</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41563-018-0099-0</ELocationID><Abstract><AbstractText>Islet transplantation is a promising therapy for type 1 diabetes. However, chronic immunosuppression to control rejection of allogeneic islets induces morbidities and impairs islet function. T effector cells are responsible for islet allograft rejection and express Fas death receptors following activation, becoming sensitive to Fas-mediated apoptosis. Here, we report that localized immunomodulation using microgels presenting an apoptotic form of the Fas ligand with streptavidin (SA-FasL) results in prolonged survival of allogeneic islet grafts in diabetic mice. A short course of rapamycin treatment boosted the immunomodulatory efficacy of SA-FasL microgels, resulting in acceptance and function of allografts over 200 days. Survivors generated normal systemic responses to donor antigens, implying immune privilege of the graft, and had increased CD4<sup>+</sup>CD25<sup>+</sup>FoxP3<sup>+</sup> T regulatory cells in the graft and draining lymph nodes. Deletion of T regulatory cells resulted in acute rejection of established islet allografts. This localized immunomodulatory biomaterial-enabled approach may provide an alternative to chronic immunosuppression for clinical islet transplantation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Headen</LastName><ForeName>Devon M</ForeName><Initials>DM</Initials><AffiliationInfo><Affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Woodward</LastName><ForeName>Kyle B</ForeName><Initials>KB</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coronel</LastName><ForeName>María M</ForeName><Initials>MM</Initials><AffiliationInfo><Affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shrestha</LastName><ForeName>Pradeep</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Weaver</LastName><ForeName>Jessica D</ForeName><Initials>JD</Initials><AffiliationInfo><Affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhao</LastName><ForeName>Hong</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tan</LastName><ForeName>Min</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hunckler</LastName><ForeName>Michael D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bowen</LastName><ForeName>William S</ForeName><Initials>WS</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Christopher T</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shea</LastName><ForeName>Lonnie</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yolcu</LastName><ForeName>Esma S</ForeName><Initials>ES</Initials><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>García</LastName><ForeName>Andrés J</ForeName><Initials>AJ</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6602-2518</Identifier><AffiliationInfo><Affiliation>Woodruff School of Mechanical Engineering, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA. andres.garcia@me.gatech.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shirwan</LastName><ForeName>Haval</ForeName><Initials>H</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-1657-9470</Identifier><AffiliationInfo><Affiliation>Institute for Cellular Therapeutics, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, University of Louisville, Louisville, KY, USA. haval.shirwan@louisville.edu.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>F30 AR069472</GrantID><Acronym>AR</Acronym><Agency>NIAMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T90 DK097787</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>T32 GM008169</GrantID><Acronym>GM</Acronym><Agency>NIGMS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>S10 OD016264</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>U01 AI132817</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 EB020107</GrantID><Acronym>EB</Acronym><Agency>NIBIB NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 AI113348</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK020572</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R56 AI121281</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>06</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Mater</MedlineTA><NlmUniqueID>101155473</NlmUniqueID><ISSNLinking>1476-1122</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001672">Biocompatible Materials</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053222">Fas Ligand Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>9013-20-1</RegistryNumber><NameOfSubstance UI="D019809">Streptavidin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001672" MajorTopicYN="N">Biocompatible Materials</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053222" MajorTopicYN="N">Fas Ligand Protein</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D056747" MajorTopicYN="N">Immunomodulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016381" MajorTopicYN="N">Islets of Langerhans Transplantation</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019809" MajorTopicYN="N">Streptavidin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014184" MajorTopicYN="N">Transplantation, Homologous</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>02</Month><Day>04</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2018</Year><Month>04</Month><Day>18</Day></PubMedPubDate><PubMedPubDate 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Headen</name></region><name sortKey="Bowen, William S" sort="Bowen, William S" uniqKey="Bowen W" first="William S" last="Bowen">William S. Bowen</name><name sortKey="Coronel, Maria M" sort="Coronel, Maria M" uniqKey="Coronel M" first="María M" last="Coronel">María M. Coronel</name><name sortKey="Coronel, Maria M" sort="Coronel, Maria M" uniqKey="Coronel M" first="María M" last="Coronel">María M. Coronel</name><name sortKey="Garcia, Andres J" sort="Garcia, Andres J" uniqKey="Garcia A" first="Andrés J" last="García">Andrés J. García</name><name sortKey="Garcia, Andres J" sort="Garcia, Andres J" uniqKey="Garcia A" first="Andrés J" last="García">Andrés J. García</name><name sortKey="Headen, Devon M" sort="Headen, Devon M" uniqKey="Headen D" first="Devon M" last="Headen">Devon M. Headen</name><name sortKey="Hunckler, Michael D" sort="Hunckler, Michael D" uniqKey="Hunckler M" first="Michael D" last="Hunckler">Michael D. Hunckler</name><name sortKey="Hunckler, Michael D" sort="Hunckler, Michael D" uniqKey="Hunckler M" first="Michael D" last="Hunckler">Michael D. Hunckler</name><name sortKey="Johnson, Christopher T" sort="Johnson, Christopher T" uniqKey="Johnson C" first="Christopher T" last="Johnson">Christopher T. Johnson</name><name sortKey="Johnson, Christopher T" sort="Johnson, Christopher T" uniqKey="Johnson C" first="Christopher T" last="Johnson">Christopher T. Johnson</name><name sortKey="Shea, Lonnie" sort="Shea, Lonnie" uniqKey="Shea L" first="Lonnie" last="Shea">Lonnie Shea</name><name sortKey="Shea, Lonnie" sort="Shea, Lonnie" uniqKey="Shea L" first="Lonnie" last="Shea">Lonnie Shea</name><name sortKey="Shirwan, Haval" sort="Shirwan, Haval" uniqKey="Shirwan H" first="Haval" last="Shirwan">Haval Shirwan</name><name sortKey="Shirwan, Haval" sort="Shirwan, Haval" uniqKey="Shirwan H" first="Haval" last="Shirwan">Haval Shirwan</name><name sortKey="Shrestha, Pradeep" sort="Shrestha, Pradeep" uniqKey="Shrestha P" first="Pradeep" last="Shrestha">Pradeep Shrestha</name><name sortKey="Shrestha, Pradeep" sort="Shrestha, Pradeep" uniqKey="Shrestha P" first="Pradeep" last="Shrestha">Pradeep Shrestha</name><name sortKey="Tan, Min" sort="Tan, Min" uniqKey="Tan M" first="Min" last="Tan">Min Tan</name><name sortKey="Weaver, Jessica D" sort="Weaver, Jessica D" uniqKey="Weaver J" first="Jessica D" last="Weaver">Jessica D. Weaver</name><name sortKey="Weaver, Jessica D" sort="Weaver, Jessica D" uniqKey="Weaver J" first="Jessica D" last="Weaver">Jessica D. Weaver</name><name sortKey="Woodward, Kyle B" sort="Woodward, Kyle B" uniqKey="Woodward K" first="Kyle B" last="Woodward">Kyle B. Woodward</name><name sortKey="Woodward, Kyle B" sort="Woodward, Kyle B" uniqKey="Woodward K" first="Kyle B" last="Woodward">Kyle B. Woodward</name><name sortKey="Yolcu, Esma S" sort="Yolcu, Esma S" uniqKey="Yolcu E" first="Esma S" last="Yolcu">Esma S. Yolcu</name><name sortKey="Yolcu, Esma S" sort="Yolcu, Esma S" uniqKey="Yolcu E" first="Esma S" last="Yolcu">Esma S. Yolcu</name><name sortKey="Zhao, Hong" sort="Zhao, Hong" uniqKey="Zhao H" first="Hong" last="Zhao">Hong Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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